Proteomic Alterations in Human Dermal Fibroblasts under Photo-Induced Pollution Caused by Excessive Solar Irradiations such as Infra-Red, Blue Light, UVA and UVB

Background: The skin serves as the first line of defense for human body. Direct sunlight contains damaging radiations that can speed up ageing process skin, resulting in wrinkles, leathery dark patches, and solar elastosis. Objectives: To evaluate effect multiple irradiation related factors at protein level dermal fibroblast (HDF). overall individual irradiations such Infrared A (IRA), blue light (BL), UVA, UVB on HDF cells extent molecular aberrations to be assessed compared against each. Methods: Label-free quantitative proteomics (MS/MS) approach has been adopted this study observe changes induced through various exposures full sources. Following that, downstream insilico analysis carried out. Results: In study, it is demonstrated all four different significantly contribute degeneration mechanisms. This confirms BL down-regulates DNA repair proteins cells-HDF stimulate histone a response mechanism maintain chromosomal integrity. Conclusions: experiment out current intends support future sun care products based protection technology custom designed provide complete from radiation. Similar could enhance further investigations deeper understanding induction, mode action, prevention damage extensive irradiation.